Journal of Clinical Gynecology and Obstetrics, ISSN 1927-1271 print, 1927-128X online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Gynecol Obstet and Elmer Press Inc
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Case Report

Volume 4, Number 3, September 2015, pages 275-278

Highly Elevated Level of Serum CA125 Produced by a Large Uterine Leiomyoma in a 20-Year-Old Woman


Figure 1.
Figure 1. Transvaginal ultrasonography of the pelvic region. A 15 cm mass developed from the uterus is shown. There is no evidence of ascites or necrosis. Neither ovary is detected
Figure 2.
Figure 2. H&E staining (a) and CA125 immunochemistry (b) of the tumor. The spindle-shaped tumor cells have cytologically bland, relatively uniform nuclei with fine chromatin and small nucleoli. The cytoplasm is abundant, eosinophilic and fibrillar (a). CA125 immunostaining of the same slide showed positive staining of the cytoplasm of tumor cells (b).
Figure 3.
Figure 3. The serum CA125 level (upper, green line) fell from 1,570.9 U/mL at presentation, to 197.2 U/mL 1 day after the operation, to 42.6 U/mL during the next menstruation, and finally to 23.4 U/mL, a normal level, within a month after the operation. A re-elevation of the CA125 level did not occur, even during the next menstruation period after the operation. Immediately after the operation, the serum LDH level (blue line) also dropped.