J Clin Gynecol Obstet

Journal of Clinical Gynecology and Obstetrics, ISSN 1927-1271 print, 1927-128X online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Gynecol Obstet and Elmer Press Inc

Journal website http://www.jcgo.org

Original Article

Volume 4, Number 3, September 2015, pages 251-257

Effectiveness and Safety of Cytoreduction Surgery in Advanced Ovarian Cancer: Initial Experience at a University General Hospital

**Table 1.** Characteristics of the Patients and of the Illness
	n = 34
Quantitative variables: median (range). Nominal variables: count (%).
Age	60 (41 - 84)
Tumor
Primary	22 (65%)
Recurrence	12 (35%)
Serous/Papillary-Serous	14 (41%)
Endometrioid	5 (15%)
Granular	1 (3%)
Mullerian	1 (3%)
Neuroendocrine	1 (3%)
Mixed	1 (3%)
Peritoneal	9 (26%)
Indistinct	2 (6%)
FIGO
IIIC	18 (53%)
IV	16 (47%)
ASA
I	1 (3%)
II	9 (26%)
III	23 (68%)
IV	1 (3%)
IPC operative	12 (2 - 33)
1 - 10	13 (38%)
11 - 20	13 (38%)
20	8 (24%)
Primary	14 (4 - 33)
Recurrence	5 (2 - 24)
CEA	2 (1 - 150)
CA199	17 (3 - 67)
CA125	254 (24 - 14,125)
CA153	115 (5 - 1,500)
Ascites (clinically evident)	9 (26%)
Pleural spillage (radiological)	7 (21%)
Intestinal subocclusion	4 (12%)
Primary	2 (9%)
Recurrence	2 (17%)
Preoperative laparoscopy	19 (56%)
IPC 1 - 10	6 (18%)
IPC 11 - 20	11 (32%)
IPC +20	2 (6%)
IPC 1 - 10 accuracy	33%
IPC +10 accuracy	63%

Table 1. Characteristics of the Patients and of the Illness

n = 34

Quantitative variables: median (range). Nominal variables: count (%).

Age

60 (41 - 84)

Tumor

Primary

22 (65%)

Recurrence

12 (35%)

Serous/Papillary-Serous

14 (41%)

Endometrioid

5 (15%)

Granular

1 (3%)

Mullerian

1 (3%)

Neuroendocrine

1 (3%)

Mixed

1 (3%)

Peritoneal

9 (26%)

Indistinct

2 (6%)

FIGO

IIIC

18 (53%)

16 (47%)

ASA

1 (3%)

9 (26%)

III

23 (68%)

1 (3%)

IPC operative

12 (2 - 33)

1 - 10

13 (38%)

11 - 20

13 (38%)

8 (24%)

Primary

14 (4 - 33)

Recurrence

5 (2 - 24)

CEA

2 (1 - 150)

CA199

17 (3 - 67)

CA125

254 (24 - 14,125)

CA153

115 (5 - 1,500)

Ascites (clinically evident)

9 (26%)

Pleural spillage (radiological)

7 (21%)

Intestinal subocclusion

4 (12%)

Primary

2 (9%)

Recurrence

2 (17%)

Preoperative laparoscopy

19 (56%)

IPC 1 - 10

6 (18%)

IPC 11 - 20

11 (32%)

IPC +20

2 (6%)

IPC 1 - 10 accuracy

33%

IPC +10 accuracy

63%

**Table 2.** Treatment and Results
	n = 34
Quantitative variables: median (range). Nominal variables: count (%).
Visceral resections	30 (88%)
Visceral resections per patient
0	5 (15%)
1	1 (3%)
2	9 (26%)
3	5 (15%)
4	3 (9%)
5	2 (6%)
7	5 (15%) visceral resections
8	2 (6%)
11	1 (3%)
14	1 (3%)
Peritonectomy (all)
Complete	21 (62%)
Partial	7 (21%)
No	6 (17%)
Primary
Complete	18 (82%)
Partial	3 (14%)
No	1 (4%)
Relapse
Complete	3 (25%)
Partial	4 (33%)
No	5 (42%)
Duration of surgery (min)	540 (280 - 750)
Primary	540 (390 - 750)
Relapse	480 (280 - 720)
Regulated lymphadenectomies	27 (80%)
Lymph nodes analyzed	26 (1 - 88)
Lymph nodes positive	2 (0 - 36)
Infrarenal aorta caval lymphadenectomy	27 (80%)
Lymph nodes analyzed	12 (1 - 28)
Lymph nodes positive	1 (0 - 12)
Left iliac pelvic lymphadenectomy	23 (66%)
Lymph nodes analyzed	7 (1 - 29)
Lymph nodes positive	1 (0 - 11)
Right iliac pelvic lymphadenectomy	22 (65%)
Lymph nodes analyzed	7 (1 - 19)
Lymph nodes positive	1 (0 - 15)
Supsramesocolic lymphadenectomy	5 (15%)
Lymph nodes analyzed	2 (1 - 9)
Lymph nodes positive	1 (0 - 2)
Cytoreduction
CC0	27 (79%)
CC1	4 (12%)
CC2	2 (6%)
CC3	1 (3%)
Cytoreducion CC0
Primary	19 (70%)
Relapse	8 (30%)
Cytoreduction CC1
Primary	2 (50%)
Relapse	2 (50%)
Cytoreduction CC2
Primary	2 (100%)
Relapse	0
Cytoreduction CC3
Primary	0
Relapse	1 (100%)
Complications	19 (56%)
Digestive fistulas	3 (9%)
Reoperation	6 (18%)
Death 90 days	2 (6%)
Stay in ICU	6 (2 - 36)
Postoperative stay	22 (8 - 63)
Stay > 20 days	20 (59%)
Primary	27 (10 - 56)
Relapse	14 (8 - 63)

Table 2. Treatment and Results

n = 34

Quantitative variables: median (range). Nominal variables: count (%).

Visceral resections

30 (88%)

Visceral resections per patient

5 (15%)

1 (3%)

9 (26%)

5 (15%)

3 (9%)

2 (6%)

5 (15%) visceral resections

2 (6%)

1 (3%)

Peritonectomy (all)

Complete

21 (62%)

Partial

7 (21%)

6 (17%)

Primary

Complete

18 (82%)

Partial

3 (14%)

1 (4%)

Relapse

Complete

3 (25%)

Partial

4 (33%)

5 (42%)

Duration of surgery (min)

540 (280 - 750)

Primary

540 (390 - 750)

Relapse

480 (280 - 720)

Regulated lymphadenectomies

27 (80%)

Lymph nodes analyzed

26 (1 - 88)

Lymph nodes positive

2 (0 - 36)

Infrarenal aorta caval lymphadenectomy

27 (80%)

Lymph nodes analyzed

12 (1 - 28)

Lymph nodes positive

1 (0 - 12)

Left iliac pelvic lymphadenectomy

23 (66%)

Lymph nodes analyzed

7 (1 - 29)

Lymph nodes positive

1 (0 - 11)

Right iliac pelvic lymphadenectomy

22 (65%)

Lymph nodes analyzed

7 (1 - 19)

Lymph nodes positive

1 (0 - 15)

Supsramesocolic lymphadenectomy

5 (15%)

Lymph nodes analyzed

2 (1 - 9)

Lymph nodes positive

1 (0 - 2)

Cytoreduction

CC0

27 (79%)

CC1

4 (12%)

CC2

2 (6%)

CC3

1 (3%)

Cytoreducion CC0

Primary

19 (70%)

Relapse

8 (30%)

Cytoreduction CC1

Primary

2 (50%)

Relapse

2 (50%)

Cytoreduction CC2

Primary

2 (100%)

Relapse

Cytoreduction CC3

Primary

Relapse

1 (100%)

Complications

19 (56%)

Digestive fistulas

3 (9%)

Reoperation

6 (18%)

Death 90 days

2 (6%)

Stay in ICU

6 (2 - 36)

Postoperative stay

22 (8 - 63)

Stay > 20 days

20 (59%)

Primary

27 (10 - 56)

Relapse

14 (8 - 63)

**Table 3.** Visceral Resections in Order of Frequency
Organ	n	%
Sigmoid colon	18	53
Small intestine	14	41
Cecum and appendiz	13	38
Gallbladder	12	35
Rectum	11	32
Spleen	11	32
Transverse colon	7	21
Ascending colon	5	15
Pancreas body-tail	5	15
Hepatic peritoneum	5	15
Partial bladder	4	12
Descending colon	4	12
Liver	4	12
Diaphragm	4	12
Total bladder	3	9
Ureter	3	9
Major vessels	3	9
Stomach	2	6
Kidney	2	6
Adrenal	2	6
Total	30 cases	88%

Table 3. Visceral Resections in Order of Frequency

Organ

Sigmoid colon

Small intestine

Cecum and appendiz

Gallbladder

Rectum

Spleen

Transverse colon

Ascending colon

Pancreas body-tail

Hepatic peritoneum

Partial bladder

Descending colon

Liver

Diaphragm

Total bladder

Ureter

Major vessels

Stomach

Kidney

Adrenal

Total

30 cases

88%