Journal of Clinical Gynecology and Obstetrics, ISSN 1927-1271 print, 1927-128X online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Gynecol Obstet and Elmer Press Inc
Journal website http://www.jcgo.org

Original Article

Volume 4, Number 3, September 2015, pages 251-257


Effectiveness and Safety of Cytoreduction Surgery in Advanced Ovarian Cancer: Initial Experience at a University General Hospital

Figures

Figure 1.
Figure 1. Graphs reproducing areas described in the process proposed by Morrow [8].
Figure 2.
Figure 2. Curves of survival at the follow-up year (Kaplan-Meier).

Tables

Table 1. Characteristics of the Patients and of the Illness
 
n = 34
Quantitative variables: median (range). Nominal variables: count (%).
Age60 (41 - 84)
Tumor
  Primary22 (65%)
  Recurrence12 (35%)
  Serous/Papillary-Serous14 (41%)
  Endometrioid5 (15%)
  Granular1 (3%)
  Mullerian1 (3%)
  Neuroendocrine1 (3%)
  Mixed1 (3%)
  Peritoneal9 (26%)
  Indistinct2 (6%)
FIGO
  IIIC18 (53%)
  IV16 (47%)
ASA
  I1 (3%)
  II9 (26%)
  III23 (68%)
  IV1 (3%)
IPC operative12 (2 - 33)
  1 - 1013 (38%)
  11 - 2013 (38%)
  208 (24%)
  Primary14 (4 - 33)
  Recurrence5 (2 - 24)
CEA2 (1 - 150)
CA19917 (3 - 67)
CA125254 (24 - 14,125)
CA153115 (5 - 1,500)
Ascites (clinically evident)9 (26%)
Pleural spillage (radiological)7 (21%)
Intestinal subocclusion4 (12%)
  Primary2 (9%)
  Recurrence2 (17%)
Preoperative laparoscopy19 (56%)
  IPC 1 - 106 (18%)
  IPC 11 - 2011 (32%)
  IPC +202 (6%)
  IPC 1 - 10 accuracy33%
  IPC +10 accuracy63%

 

Table 2. Treatment and Results
 
n = 34
Quantitative variables: median (range). Nominal variables: count (%).
Visceral resections30 (88%)
Visceral resections per patient
  05 (15%)
  11 (3%)
  29 (26%)
  35 (15%)
  43 (9%)
  52 (6%)
  75 (15%) visceral resections
  82 (6%)
  111 (3%)
  141 (3%)
Peritonectomy (all)
  Complete21 (62%)
  Partial7 (21%)
  No6 (17%)
  Primary
    Complete18 (82%)
    Partial3 (14%)
    No1 (4%)
  Relapse
    Complete3 (25%)
    Partial4 (33%)
    No5 (42%)
Duration of surgery (min)540 (280 - 750)
  Primary540 (390 - 750)
  Relapse480 (280 - 720)
Regulated lymphadenectomies27 (80%)
  Lymph nodes analyzed26 (1 - 88)
  Lymph nodes positive2 (0 - 36)
Infrarenal aorta caval lymphadenectomy27 (80%)
  Lymph nodes analyzed12 (1 - 28)
  Lymph nodes positive1 (0 - 12)
Left iliac pelvic lymphadenectomy23 (66%)
  Lymph nodes analyzed7 (1 - 29)
  Lymph nodes positive1 (0 - 11)
Right iliac pelvic lymphadenectomy22 (65%)
  Lymph nodes analyzed7 (1 - 19)
  Lymph nodes positive1 (0 - 15)
Supsramesocolic lymphadenectomy5 (15%)
  Lymph nodes analyzed2 (1 - 9)
  Lymph nodes positive1 (0 - 2)
Cytoreduction
  CC027 (79%)
  CC14 (12%)
  CC22 (6%)
  CC31 (3%)
Cytoreducion CC0
  Primary19 (70%)
  Relapse8 (30%)
Cytoreduction CC1
  Primary2 (50%)
  Relapse2 (50%)
Cytoreduction CC2
  Primary2 (100%)
  Relapse0
Cytoreduction CC3
  Primary0
  Relapse1 (100%)
Complications19 (56%)
Digestive fistulas3 (9%)
Reoperation6 (18%)
Death 90 days2 (6%)
Stay in ICU6 (2 - 36)
Postoperative stay22 (8 - 63)
  Stay > 20 days20 (59%)
  Primary27 (10 - 56)
  Relapse14 (8 - 63)

 

Table 3. Visceral Resections in Order of Frequency
 
Organn%
Sigmoid colon1853
Small intestine1441
Cecum and appendiz1338
Gallbladder1235
Rectum1132
Spleen1132
Transverse colon721
Ascending colon515
Pancreas body-tail515
Hepatic peritoneum515
Partial bladder412
Descending colon412
Liver412
Diaphragm412
Total bladder39
Ureter39
Major vessels39
Stomach26
Kidney26
Adrenal26
Total30 cases88%