J Clin Gynecol Obstet

Journal of Clinical Gynecology and Obstetrics, ISSN 1927-1271 print, 1927-128X online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Gynecol Obstet and Elmer Press Inc

Journal website http://www.jcgo.org

Original Article

Volume 6, Number 3-4, October 2017, pages 58-64

Efficacy, Safety, and Acceptability of Thermal Coagulation to Treat Cervical Intraepithelial Neoplasia: Pooled Data From Bangladesh, Brazil and India

**Table 1.** Characteristics of Women Treated for CIN at Baseline
Characteristics	Women treated at baseline, n (%)
*Percentages obtained from the total of 1,475 participants for the three sites that provided the information. CIN: cervical intraepithelial neoplasia.
Women assessed	1,626
Site (period)
Dhaka, Bangladesh (January 2010 - December 2015)	1,294 (79.6%)
Porto Alegre, Brazil (November 2010 - November 2015)	99 (6.1%)
Ambillikai, India (March 2009 - October 2015)	96 (5.9%)
Pune, India (October 2010 - November 2011)	83 (5.1%)
Trivandrum, India (November 2008 - February 2012)	54 (3.3%)
Age (years)
< 40	1,272 (78.3%)
40+	352 (21.7%)
Education
Illiterate	310 (19.2%)
Primary	639 (39.7%)
Middle	317 (19.7%)
High school and above	345 (21.4%)
Number of pregnancies*
0 - 1	321 (21.8%)
2 - 3	914 (62.0%)
4+	240 (16.3%)
Baseline histological diagnosis
CIN 1	1,284 (79.0%)
CIN 2	221 (13.6%)
CIN 3	121 (7.4%)

Table 1. Characteristics of Women Treated for CIN at Baseline

Characteristics

Women treated at baseline, n (%)

*Percentages obtained from the total of 1,475 participants for the three sites that provided the information. CIN: cervical intraepithelial neoplasia.

Women assessed

1,626

Site (period)

Dhaka, Bangladesh (January 2010 - December 2015)

1,294 (79.6%)

Porto Alegre, Brazil (November 2010 - November 2015)

99 (6.1%)

Ambillikai, India (March 2009 - October 2015)

96 (5.9%)

Pune, India (October 2010 - November 2011)

83 (5.1%)

Trivandrum, India (November 2008 - February 2012)

54 (3.3%)

Age (years)

< 40

1,272 (78.3%)

40+

352 (21.7%)

Education

Illiterate

310 (19.2%)

Primary

639 (39.7%)

Middle

317 (19.7%)

High school and above

345 (21.4%)

Number of pregnancies*

0 - 1

321 (21.8%)

2 - 3

914 (62.0%)

240 (16.3%)

Baseline histological diagnosis

CIN 1

1,284 (79.0%)

CIN 2

221 (13.6%)

CIN 3

121 (7.4%)

**Table 2.** Determinants of Treatment Follow-Up
Characteristics	Women treated for CIN at baseline	Women with follow-up, n (%)	Adjusted odds ratio (95% CI)*
All variables included in the adjusted regression model. *Percentages obtained from the total of 1,475 participants for the three sites that provided the information. CI: confidence interval; CIN: cervical intraepithelial neoplasia.
Women assessed	1,626	775 (47.7%)
Age (years)
< 40	1,272	625 (49.1%)	1.0
40+	352	149 (42.3%)	0.7 (0.5 - 0.9)
Education
Illiterate	310	102 (32.9%)	1.0
Primary	639	256 (40.1%)	1.4 (1.0 -1.8)
Middle	317	187 (59.0%)	2.7 (1.9 -3.7)
High school and above	345	215 (62.3%)	3.2 (2.2 -4.4)
Number of pregnancies**
0 - 1	321	167 (52.0%)	1.0
2 - 3	914	434 (47.5%)	1.1 (0.8 -1.5)
4+	240	98 (40.8%)	1.0 (0.6 -1.4)
Baseline histological diagnosis
CIN 1	1,284	543 (42.3%)	1.0
CIN 2	221	137 (62.0%)	2.3 (1.7 -3.1)
CIN 3	121	95 (78.5%)	4.8 (2.8 -7.4)

Table 2. Determinants of Treatment Follow-Up

Characteristics

Women treated for CIN at baseline

Women with follow-up, n (%)

Adjusted odds ratio (95% CI)*

*All variables included in the adjusted regression model. **Percentages obtained from the total of 1,475 participants for the three sites that provided the information. CI: confidence interval; CIN: cervical intraepithelial neoplasia.

Women assessed

1,626

775 (47.7%)

Age (years)

< 40

1,272

625 (49.1%)

1.0

40+

352

149 (42.3%)

0.7 (0.5 - 0.9)

Education

Illiterate

310

102 (32.9%)

1.0

Primary

639

256 (40.1%)

1.4 (1.0 -1.8)

Middle

317

187 (59.0%)

2.7 (1.9 -3.7)

High school and above

345

215 (62.3%)

3.2 (2.2 -4.4)

Number of pregnancies**

0 - 1

321

167 (52.0%)

1.0

2 - 3

914

434 (47.5%)

1.1 (0.8 -1.5)

240

98 (40.8%)

1.0 (0.6 -1.4)

Baseline histological diagnosis

CIN 1

1,284

543 (42.3%)

1.0

CIN 2

221

137 (62.0%)

2.3 (1.7 -3.1)

CIN 3

121

95 (78.5%)

4.8 (2.8 -7.4)

**Table 3.** Effect of Women Characteristics on CIN Cure Rates After Treatment With Thermal Coagulation
Characteristics	Women with follow-up	Women with no evidence of disease during follow-up, n (%)	Crude hazard ratio (95% CI)	Adjusted hazard ratio (95% CI)*
All variables included in the adjusted regression model. *Percentages obtained from the total of 699 participants for the three sites that provided the information. CI: confidence interval; CIN: cervical intraepithelial neoplasia.
Women assessed	775	667 (86.1%)
Age (years)
< 40	625	538 (86.1%)	1.0	1.0
40+	149	128 (85.9%)	1.1 (0.9 - 1.4)	1.1 (0.9 - 1.4)
Number of pregnancies**
0 - 1	167	135 (80.8%)	1.0	1.0
2 - 3	434	386 (88.9%)	1.3 (1.1 - 1.6)	1.3 (1.1 - 1.6)
4+	98	84 (85.7%)	1.1 (0.8 - 1.5)	1.1 (0.8 - 1.4)
Baseline histological diagnosis
CIN 1	543	475 (87.5%)	1.0	1.0
CIN 2	137	113 (82.5%)	1.1 (0.9 - 1.4)	1.2 (0.9 - 1.4)
CIN 3	95	79 (83.2%)	1.1 (0.9 - 1.4)	1.2 (0.9 - 1.5)

Table 3. Effect of Women Characteristics on CIN Cure Rates After Treatment With Thermal Coagulation

Characteristics

Women with follow-up

Women with no evidence of disease during follow-up, n (%)

Crude hazard ratio (95% CI)

Adjusted hazard ratio (95% CI)*

*All variables included in the adjusted regression model. **Percentages obtained from the total of 699 participants for the three sites that provided the information. CI: confidence interval; CIN: cervical intraepithelial neoplasia.

Women assessed

775

667 (86.1%)

Age (years)

< 40

625

538 (86.1%)

1.0

40+

149

128 (85.9%)

1.1 (0.9 - 1.4)

Number of pregnancies**

0 - 1

167

135 (80.8%)

1.0

2 - 3

434

386 (88.9%)

1.3 (1.1 - 1.6)

84 (85.7%)

1.1 (0.8 - 1.5)

1.1 (0.8 - 1.4)

Baseline histological diagnosis

CIN 1

543

475 (87.5%)

1.0

CIN 2

137

113 (82.5%)

1.1 (0.9 - 1.4)

1.2 (0.9 - 1.4)

CIN 3

79 (83.2%)

1.1 (0.9 - 1.4)

1.2 (0.9 - 1.5)