Figure 1. CONSORT flow diagram of participant recruitment, enrollment, randomization, follow-up, and analysis. CONSORT: Consolidated Standards of Reporting Trials.
| Journal of Clinical Gynecology and Obstetrics, ISSN 1927-1271 print, 1927-128X online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Clin Gynecol Obstet and Elmer Press Inc |
| Journal website https://www.jcgo.org |
Original Article
Volume 9, Number 4, December 2020, pages 96-101
Gabapentin for Peri-Operative Pain Relief in Office Gynecological Surgery: A Double-Blind Randomized Controlled Trial
Figure
Tables
| Characteristic | Gabapentin (n = 107) | Placebo (n = 109) | Total (n = 216) |
|---|---|---|---|
| Data are presented as mean (SD) or N (%). aMissing data are excluded from percentage calculations (gabapentin = 82; placebo = 88; total = 170). SD: standard deviation. | |||
| Age | 27.7 (6.26) | 27.1 (6.03) | 27.4 (6.13) |
| Race/ethnicity | |||
| Hispanic/Latino | 36 (33.6) | 47 (43.1) | 83 (38.4) |
| White/Caucasian | 53 (49.5) | 39 (36.1) | 92 (42.8) |
| Black/African American | 20 (18.7) | 18 (16.7) | 38 (17.7) |
| Asian | 6 (5.6) | 5 (4.6) | 11 (5.1) |
| Hawaiian/Pacific Islander | 3 (2.8) | 0 (0.0) | 3 (1.4) |
| American/Alaskan Native | 5 (4.7) | 3 (2.8) | 8 (3.7) |
| Other | 17 (15.9) | 33 (30.6) | 50 (23.3) |
| More than one | 3 (2.8) | 10 (9.3) | 13 (6.0) |
| Living arrangements | |||
| Alone | 13 (12.1) | 10 (9.2) | 23 (10.6) |
| With partner | 44 (41.1) | 46 (42.2) | 90 (41.7) |
| With children | 28 (26.2) | 44 (40.4) | 72 (33.3) |
| With friends | 7 (6.5) | 7 (6.4) | 14 (6.5) |
| With family | 37 (34.6) | 35 (32.1) | 72 (33.3) |
| Pregnancy history | |||
| Previous pregnancies (“Yes”) | 82 (76.6) | 88 (80.7) | 170 (78.7) |
| History of vaginal deliveriesa | 40 (48.8) | 59 (67.0) | 99 (58.2) |
| History of cesarean deliveriesa | 18 (22.0) | 23 (26.1) | 41 (24.1) |
| History of abortionsa | 51 (62.2) | 47 (53.4) | 98 (57.6) |
| History of miscarriagesa | 23 (28.0) | 20 (22.7) | 43 (25.3) |
| History of stillbirthsa | 0 (0.0) | 4 (4.5) | 4 (2.4) |
| History of ectopic pregnanciesa | 0 (0.0) | 5 (5.7) | 5 (2.9) |
| History of prior surgical abortions | 46 (43.0) | 44 (40.4) | 90 (41.7) |
| Gestational age | |||
| 5 - 12 weeks | 73 (68.2) | 73 (67.0) | 146 (67.6) |
| 13 - 18 weeks | 30 (28.0) | 32 (29.4) | 62 (28.7) |
| 19 - 24 weeks | 4 (3.7) | 4 (3.7) | 8 (3.7) |
| Characteristic | Gabapentin | Placebo | Total |
|---|---|---|---|
| Data are presented as median (Q1, Q3; n). | |||
| Nervousness | |||
| Nervous about surgery | 63 (63, 86; 107) | 60 (35.5, 84.5; 109) | 63 (34, 85.75; 216) |
| Nervous about expected pain | 65 (39, 89; 107) | 63 (36.5, 88; 109) | 64 (39, 88.75; 216) |
| Pain | |||
| Expected pain with procedure | 55 (34, 68; 107) | 53 (25, 69.5; 109) | 53.5 (30.25, 69; 216) |
| Baseline | 0 (0, 3; 107) | 0 (0, 4; 109) | 0 (0, 4; 216) |
| 5 min | 17 (0, 60; 107) | 17 (2, 53; 109) | 17 (1, 56.5; 216) |
| 30 min | 20 (3, 55; 107) | 23 (3, 57; 109) | 21.5 (3, 56.75; 216) |
| 24 h | 0 (0, 20; 67) | 1 (0, 12.5; 61) | 1 (0, 13.75; 128) |
| Satisfaction | |||
| Surgical procedure (24 h) | 100 (90, 100; 67) | 100 (100, 100; 61) | 100 (100, 100; 128) |
| Entire procedure | 96 (85, 100; 107) | 97 (84.5, 100; 109) | 96 (85, 100; 216) |
| With pain control (30 min) | 90 (70, 98; 107) | 92 (73.5, 99; 109) | 91.5 (71.25, 99; 216) |
| With pain control (24 h) | 100 (80, 100; 67) | 100 (80, 100; 61) | 100 (80, 100; 128) |