Journal of Clinical Gynecology and Obstetrics, ISSN 1927-1271 print, 1927-128X online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Gynecol Obstet and Elmer Press Inc
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Case Report

Volume 10, Number 2, June 2021, pages 51-54

Successful Management of Significant Maternal 3 Beta-Hydroxysteroid Dehydrogenase Deficiency


Figure 1.
Figure 1. Ovarian steroidogenesis, the role of 3β-HSD in the conversion of DHEA to androgens and estrogens in the adrenal glands and gonads. 3β-HSD: 3β-hydroxysteroid dehydrogenase; DHEA: dehydroepiandrosterone.


Table 1. Results of ACTH (Cortrosyn®) Stimulation Test
Time zero (normal values)1 h elapsed
ACTH: adrenocorticotropic hormone; DHEA: dehydroepiandrosterone.
17-hydroxyprogesterone392 mg/dL (10 - 120 mg/dL)271 mg/dL
Pregnenolone199 ng/dL497 ng/dL
17-hydroxypregnenolone161 ng/dL (53 - 357 ng/dL)705 ng/dL
DHEA3.9 ng/mL (1.9 - 7.6 ng/mL)8.2 ng/mL
11-deoxycortisol0.2 µg/dL (7 - 25 µg/dL)0.3 µg/dL
Cortisol16 µg/dL (7 - 25 µg/dL)27 µg/dL
Testosterone25 ng/dL (14 - 76 ng/dL)22 ng/dL