Report on Repeated Mifepristone Treatment for Uterine Fibroids or Endometriosis

Josep Lluis Carbonell Esteve, Acosta Rita, Perez Yasmirian, Riveron Ana Maria, Gonzalez Jesus, Sanchez Carlos, Tomasi Giuseppe


Background: No information is available on how repeated administration of mifepristone could affect women’s health.

Methods: A total of 101 and 36 subjects who participated in up to 2 and 3 mifepristone trials to treat endometriosis or uterine fibroids, respectively, carried out at the “Eusebio Hernandez” Hospital, Havana, Cuba.

Results: Subjects who repeated mifepristone to treat fibroids did so for 7.3 ± 2.5 months, minimum and maximum of 6 and 15 months, respectively. The average rest interval was 9.7 ± 6.2 months, minimum and maximum of 3 and 30 months, respectively. In subjects repeating mifepristone for endometriosis, the average was 18 ± 2.0, with a minimum and maximum of 12 and 24 months, respectively. The average rest interval was 8.3 ± 5.3 months, 95% CI = 7.6 - 8.9, minimum and maximum of 3 and 30 months, respectively. No change in women’s health was detected months after termination of final mifepristone treatment.

Conclusions: Repeating low doses mifepristone treatment up to 3 - 4 times for 3, 6 or 9 months duration with variable rest intervals between sessions, did not seem to involve any risk to health. More studies to confirm the long-term safety of repeated low dosage mifepristone are mandatory.



Mifepristone; Fibroid; Endometriosis; Antiprogestins; Repeated use

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Journal of Clinical Gynecology and Obstetrics, quarterly, ISSN 1927-1271 (print), 1927-128X (online), published by Elmer Press Inc.                     
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