Recurrent Non-Peutz-Jeghers Syndrome Associated Ovarian Sex Cord Tumor With Annular Tubules: A Case Report With Literature Review

Amal Abd El-hafez Abd El-mageed, Amir Monir Shafik

Abstract


This report describes the late recurrence of an unusual ovarian neoplasm namely sex cord stromal tumor with annular tubules (SCTAT). This tumor was detected in a non-Peutz-Jeghers syndrome (PJS) female patient aging 54-years after 9 years of primary surgery. The patient undergone pelvic ultrasonography and MRI followed by laparotomy for frozen section. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. Microscopic examination revealed diagnostic features of SCTAT. A review of the literature reporting the clinico-pathologic features, differential diagnosis and the biologic behavior of SCTAT in patients with and without PJS is presented. In addition immunohistochemical profile was assessed for sex cord tumor markers. This report highlights the importance of considering the pathological features and behavior of SCTAT during the diagnosis and management of patients with ovarian neoplasia.




doi: http://dx.doi.org/10.4021/jcgo141e

Keywords


Sex cord tumor with annular tubules; Immunohistochemistry; Recurrent; WT-1; Calretinin; Inhibin

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