Are Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio Predictors for Severity of Preeclampsia?

Mehmet Toptas, Hilal Asik, Muhsin Kalyoncuoglu, Esra Can, Mehmet Mustafa Can

Abstract


Background: We aimed to assess neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) levels in patients with preeclampsia (PE) compared with matched normal pregnant women and evaluate whether there is an association of PE severity with hematological paramaters.

Methods: In this study, we recruited 93 women with PE and 94 normal pregnant women matched for both maternal age and gestastional age as controls to assess the clinical, hemodynamic, and neurohormonal status of patients.

Results: There were no statistically significant differences between patients with PE and normal pregnancy with regard to the maternal age and gestation at delivery; however, patients with PE exhibited significantly higher blood pressure, proteinuria levels and parity. Maternal age, multiparity status and the complete blood count parameters including hemoglobin (Hg), white blood cell (WBC), platelets, neutrophil/lymphocyte counts, mean platelet volume (MPV), and mean corpuscular volume (MCV) were not statistically different between the groups. PLR and NLR levels were comparable between PE and normal pregnancies. Moreover, in subgroup analysis, patients with severe PE had similar NLR but lower PLR levels compared to women with mild PE.

Conclusions: PLR was found to be associated with the severity of PE, whereas NLR was not. This finding may be related to cytokine-dependent defective maternal immune activation in PE pathogenesis. In addition, PLR may also be an indirectly available and simple reflector for degree of immune activation in PE.




J Clin Gynecol Obstet. 2016;5(1):27-31
doi: http://dx.doi.org/10.14740/jcgo389w

 


Keywords


Hematologic indices; Preeclampsia severity

Full Text: HTML PDF
 

Browse  Journals  

     

Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 

 

 

 

Journal of Clinical Gynecology and Obstetrics, quarterly, ISSN 1927-1271 (print), 1927-128X (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal, the authors retain the copyright, the journal is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International
License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.jcgo.org   editorial contact: editor@jcgo.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.


Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.