Grey Platelet Syndrome and Pregnancy: A Case Report and Literature Review

Francisco Ibarguengoitia-Ochoa, Cintia Maria Sepulveda-Rivera, Sergio Emmanuel Santoyo-Rosas, Diego Arturo Gonzalez-Vazquez, Jessica Aidee Mora-Galvan, Samuel Vargas-Trujillo


Grey platelet syndrome is an uncommon hereditary platelet disorder, and is characterized by thrombocytopenia and platelet dysfunction with a specific absence of alpha-granules. Electronic microscopy is a quick test that can confirm the diagnosis. We present perinatal results of a patient with diagnosed grey platelet syndrome. We reviewed the case of a patient with grey platelet syndrome at Instituto Nacional de Perinatologia. She is 26 years old, with 21 weeks’ gestation. It is noted in initial laboratories a platelet amount of 64,000/mm3, and grey platelet syndrome is suspected, so peripheral blood smear is carried out which showed pale platelets, and electronic microscopy was performed to confirm the disorder, which showed the absence of platelet alpha-granules. A female newborn was delivered at 38.4 week of gestation by abdominal cesarean section, weighing 2,588 g, with platelet count at birth of 119,000/mm3. There is no general consensus of treatment in patients with grey platelet syndrome, and management must be multi-disciplinary between obstetrics, hematology and anesthesiology services.

J Clin Gynecol Obstet. 2019;8(2):54-56


Pregnancy; Thrombocytopenia; Syndrome; Grey platelet

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Journal of Clinical Gynecology and Obstetrics, quarterly, ISSN 1927-1271 (print), 1927-128X (online), published by Elmer Press Inc.                     
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