High-Grade Serous Carcinoma of Ovary With Choriocarcinomatous Differentiation: A Case Report and Review of Literature

Qandeel Sadiq, Radhika Sekhri, Sonali Lanjewar


Non-gestational choriocarcinoma (NGC) of the ovary is a rare, highly malignant neoplasm usually of germ cell origin. Rarely, NGC has been observed in association with ovarian epithelial neoplasms. So far 11 cases of NGC with choriocarcinomatous differentiation have been described in the relevant literature. Here we describe a case of NGC differentiation in a high-grade serous carcinoma of the ovary. A 53-year-old nulliparous, postmenopausal woman presented with abdominal pain and vaginal bleeding. Abdominal imaging revealed a complex pelvic mass and carcinomatosis. The patient underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy and peritoneal tumor debulking. Microscopic examination of the bilateral ovarian mass tissue revealed a high-grade serous carcinoma with a distinct component of choriocarcinomatous differentiation. The presence of choriocarcinomatous differentiation in epithelial malignancy is associated with a very poor prognosis. Our patient succumbed to disease within 2 months of diagnosis.

J Clin Gynecol Obstet. 2020;9(3):53-59
doi: https://doi.org/10.14740/jcgo669


Ovary; Non-gestational choriocarcinoma; High-grade serous carcinoma

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Journal of Clinical Gynecology and Obstetrics, quarterly, ISSN 1927-1271 (print), 1927-128X (online), published by Elmer Press Inc.                     
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