Annual Cervical Cancer Screening Revealed Early Stage Clear Cell Adenocarcinoma of the Uterine Cervix: A Case Report

Mai Temukai, Yoshimi Tokugawa, Takeshi Hisamatsu, Yuri Kamino, Ayuko Otoshi, Chikako Tsukahara, Takashi Miyatake, Hiromi Tsuji, Hironao Yasuoka, Masahiko Tsujimoto, Tomomi Egawa-Takata, Yukihiro Nishio


Clear cell adenocarcinoma of the uterine cervix (CCAC) is rare. We describe a case of CCAC, which was treated with complete resection without adjuvant therapy. The patient was a 42-year-old woman, who had no chief complaint. She had undergone annual cervical cancer screening, and no abnormalities had been detected in previous examinations. However, in a subsequent screening examination, cervical cytology produced negative results, but cervicovaginal erosion was observed at the uterine cervix. A detailed examination led to adenocarcinoma being suspected, and so conization was performed, resulting in a diagnosis of CCAC. A microscopic examination revealed atypical cells with clear-slightly basophilic cytoplasm, and immunohistochemical studies showed that they were positive for napsin A, p16, and AE1/3. Radical hysterectomy, pelvic lymph node dissection, and bilateral salpingo-oophorectomy were performed. Complete resection was achieved, and the postoperative diagnosis was CCAC, pT1b1N0M0, ly(-), v(-). The patient did not undergo adjuvant treatment. She is still alive and recurrence-free.

J Clin Gynecol Obstet. 2019;8(1):21-24


Clear cell carcinoma; Cervical cancer; Screening

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Journal of Clinical Gynecology and Obstetrics, quarterly, ISSN 1927-1271 (print), 1927-128X (online), published by Elmer Press Inc.                     
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